小肠有益菌可缓解大豆油脂肪酸的毒性


Title:
Resilience of small intestinal beneficial bacteria to the toxicity of soybean oil fatty acids

DOI:
10.7554/eLife.32581



Abstract:
Over the past century, soybean oil (SBO) consumption in the United States increased dramatically. The main SBO fatty acid, linoleic acid (18:2), inhibitsthe growth of lactobacilli, beneficial members of the small intestinal microbiota. Human-associated lactobacilli have declined in prevalence in Western microbiomes, but how dietary changes may have impacted their ecology is unclear. Here, we compared theandeffects of 18:2 onand. Directed evolutionin both species led to strong 18:2 resistance with mutations in genes for lipid biosynthesis, acid stress, and the cell membrane or wall. Small-intestinalpopulations in mice were unaffected by chronic and acute 18:2 exposure, yet harbored both 18:2- sensitive and resistant strains. This work shows that extant small intestinal lactobacilli are protected from toxic dietary components via the gut environment as well as their own capacity to evolve resistance.

All Authors:
Sara C Di Rienzi,Juliet Jacobson,Elizabeth A Kennedy,Mary E Bell,Qiaojuan Shi,Jillian L Waters,Peter Lawrence,J Thomas Brenna,Robert A Britton,Jens Walter,Ruth Emily Ley

First Authors:
Sara C Di Rienzi

Correspondence:
Ruth Emily Ley


摘要:

       大豆油中的主要脂肪酸亚油酸(18:2)可抑制乳酸杆菌的生长,而乳酸杆菌是小肠菌群中的有益细菌;对比18:2在体内及体外对罗伊氏乳杆菌及约氏乳杆菌的作用;体外定向进化可导致脂质生物合成、酸应激、细胞膜/细胞壁相关基因发生突变,从而使罗伊氏乳杆菌及约氏乳杆菌均对18:2产生抗性;慢性及急性的18:2暴露,不会影响小鼠小肠中的乳酸杆菌种群;最终显示肠道环境及细菌自身的进化能力,可保护小肠乳酸杆菌免受饮食成分的毒性影响。


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